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Channing Der Lab Plasmids


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Title Authors Publication
Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Khosravi-Far R, White MA, Westwick JK, Solski PA, Chrzanowska-Wodnicka M, Van Aelst L, Wigler MH, Der CJ Mol Cell Biol. 1996 Jul . 16(7):3923-33.
Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase. McFall A, Ulku A, Lambert QT, Kusa A, Rogers-Graham K, Der CJ Mol Cell Biol. 2001 Aug . 21(16):5488-99.
Two distinct Raf domains mediate interaction with Ras. Brtva TR, Drugan JK, Ghosh S, Terrell RS, Campbell-Burk S, Bell RM, Der CJ J Biol Chem. 1995 Apr 28. 270(17):9809-12.
Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth. Hao H, Muniz-Medina VM, Mehta H, Thomas NE, Khazak V, Der CJ, Shields JM Mol Cancer Ther. 2007 Aug . 6(8):2220-9.
Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. Lim KH, O'Hayer K, Adam SJ, Kendall SD, Campbell PM, Der CJ, Counter CM Curr Biol. 2006 Dec 19. 16(24):2385-94.
Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. Roberts PJ, Mitin N, Keller PJ, Chenette EJ, Madigan JP, Currin RO, Cox AD, Wilson O, Kirschmeier P, Der CJ J Biol Chem. 2008 Sep 12. 283(37):25150-63.
Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Martin TD, Chen XW, Kaplan RE, Saltiel AR, Walker CL, Reiner DJ, Der CJ Mol Cell. 2014 Jan 23;53(2):209-20. doi: 10.1016/j.molcel.2013.12.004. Epub 2014 Jan 2.
Mutant Ras Constructs (unpublished)
Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4. Mitin N, Rossman KL, Der CJ PLoS One. 2012;7(7):e41876. doi: 10.1371/journal.pone.0041876. Epub 2012 Jul 24.
RhoGDI2 antagonizes ovarian carcinoma growth, invasion and metastasis. Stevens EV, Banet N, Onesto C, Plachco A, Alan JK, Nikolaishvili-Feinberg N, Midkiff BR, Kuan PF, Liu J, Miller CR, Vigil D, Graves LM, Der CJ Small GTPases. 2011 Jul;2(4):202-210. Epub 2011 Jul 1.
ID Plasmid Gene/Insert Vector Type Publication Hidden Extra Search Info  
12543pBabe N-Ras 61KNRas 61K (Homo sapiens)Mammalian Expression, RetroviralOncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol Cell Biol. 1996 Jul . 16(7):3923-33. pBabe-Puro NRAS ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6 Add to Cart
12544pBabe K-Ras 12VK-Ras 12V (Homo sapiens)Mammalian Expression, RetroviralOncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol Cell Biol. 1996 Jul . 16(7):3923-33. pBabe-Puro KRAS C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, KI-RAS, KRAS1, KRAS2, NS, NS3, RALD, RASK2, c-Ki-ras2 Add to Cart
12545pBabe H-Ras 12VH-Ras 12V (Homo sapiens)Mammalian Expression, RetroviralOncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol Cell Biol. 1996 Jul . 16(7):3923-33. pBabe-Puro HRAS C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras Add to Cart
12588pBabe puro H-Ras 12V (35S)HRas 12V 35S (Homo sapiens)Mammalian Expression, RetroviralOncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase. Mol Cell Biol. 2001 Aug . 21(16):5488-99. pBabe puro HRAS C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras Add to Cart
12589pBabe puro H-Ras 12V (37G)HRas 12V 37G (Homo sapiens)Mammalian Expression, RetroviralOncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase. Mol Cell Biol. 2001 Aug . 21(16):5488-99. pBabe puro HRAS C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras Add to Cart
12590pBabe puro H-Ras 12V (40C)HRas 12V 40C (Homo sapiens)Mammalian Expression, RetroviralOncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase. Mol Cell Biol. 2001 Aug . 21(16):5488-99. pBabe puro HRAS C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras Add to Cart
12591pBabe hygro myc p110-CAAXp110-CAAX (Bos taurus)Mammalian Expression, RetroviralOncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase. Mol Cell Biol. 2001 Aug . 21(16):5488-99. pBabe hygro PIK3CA Add to Cart
12592pBabe HAII RLF CAAXRLF-CAAX (Mus musculus)Mammalian Expression, RetroviralOncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase. Mol Cell Biol. 2001 Aug . 21(16):5488-99. pBabe HAII Rgl2 KE1.5, Rab2l, Rgt2, Rlf Add to Cart
12593pBabe puro C-Raf 22WN-term truncated mut of Raf-1 (Homo sapiens)Mammalian Expression, RetroviralOncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase. Mol Cell Biol. 2001 Aug . 21(16):5488-99. pBabe puro RAF1 CMD1NN, CRAF, NS5, Raf-1, c-Raf Add to Cart
13338Raf-1 GST RBD 1-149Raf-1 (Homo sapiens)Bacterial ExpressionTwo distinct Raf domains mediate interaction with Ras. J Biol Chem. 1995 Apr 28. 270(17):9809-12. pGEX-2T RAF1 CMD1NN, CRAF, NS5, Raf-1, c-Raf Add to Cart
13339pBabe puro pI3K p110 CAAXpI3K p110 CAAX (Bos taurus)Mammalian Expression, RetroviralOncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase. Mol Cell Biol. 2001 Aug . 21(16):5488-99. pBabe puro PIK3CA Add to Cart
13485pBabe puro H-Ras 61LHRas 61L (Homo sapiens)Mammalian Expression, RetroviralOncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol Cell Biol. 1996 Jul . 16(7):3923-33. pBabe puro HRAS C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras Add to Cart
17544pBabe B-Raf V600EB-Raf (Homo sapiens)Mammalian Expression, RetroviralContext-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth. Mol Cancer Ther. 2007 Aug . 6(8):2220-9. pBabe-puro BRAF B-RAF1, B-raf, BRAF1, NS7, RAFB1 Add to Cart
19717pBabe puro RalA (long) wtV-ral simian leukemia viral oncogene homolog A (Homo sapiens)Mammalian Expression, RetroviralDivergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. Curr Biol. 2006 Dec 19. 16(24):2385-94. pBabe puro RALA RAL Add to Cart
19718pBabe puro RalA S31NV-ral simian leukemia viral oncogene homolog A (Homo sapiens)Mammalian Expression, RetroviralDivergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. Curr Biol. 2006 Dec 19. 16(24):2385-94. pBabe puro RALA RAL Add to Cart
19719pBabe puro RalA Q75LV-ral simian leukemia viral oncogene homolog A (Homo sapiens)Mammalian Expression, RetroviralDivergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. Curr Biol. 2006 Dec 19. 16(24):2385-94. pBabe RALA RAL Add to Cart
19720pBabe puro RalB wtV-ral simian leukemia viral oncogene homolog B (Homo sapiens)Mammalian Expression, RetroviralDivergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. Curr Biol. 2006 Dec 19. 16(24):2385-94. pBabe RALB Add to Cart
19721pBabe puro RalB Q72LV-ral simian leukemia viral oncogene homolog B (Homo sapiens)Mammalian Expression, RetroviralDivergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. Curr Biol. 2006 Dec 19. 16(24):2385-94. pBabe puro RALB Add to Cart
19722pBabe puro RalB S28NV-ral simian leukemia viral oncogene homolog B (Homo sapiens)Mammalian Expression, RetroviralDivergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. Curr Biol. 2006 Dec 19. 16(24):2385-94. pBabe puro RALB Add to Cart
19723pBabe puro RalA (short) wtV-ral simian leukemia viral oncogene homolog A (Homo sapiens)Mammalian Expression, RetroviralDivergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. Curr Biol. 2006 Dec 19. 16(24):2385-94. pBabe puro RALA RAL Add to Cart
23224GFP-RhoARhoA (Homo sapiens)Mammalian ExpressionRho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem. 2008 Sep 12. 283(37):25150-63. pEGFP-C3 RHOA ARH12, ARHA, RHO12, RHOH12 Add to Cart
23225GFP-RhoBRhoB (Rattus norvegicus)Mammalian ExpressionRho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem. 2008 Sep 12. 283(37):25150-63. pEGFP-C2 Rhob Arhb Add to Cart
23226GFP-RhoCRhoC (Homo sapiens)Mammalian ExpressionRho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem. 2008 Sep 12. 283(37):25150-63. pEGFP-C2 RHOC ARH9, ARHC, H9, RHOH9 Add to Cart
23227GFP-Rnd1Rnd1 (Homo sapiens)Mammalian ExpressionRho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem. 2008 Sep 12. 283(37):25150-63. pEGFP-C RND1 ARHS, RHO6, RHOS Add to Cart
23228GFP-Rnd2Rnd2 (Homo sapiens)Mammalian ExpressionRho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem. 2008 Sep 12. 283(37):25150-63. pEGFP-C RND2 ARHN, RHO7, RhoN Add to Cart
23229GFP-Rnd3Rnd3 (Homo sapiens)Mammalian ExpressionRho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem. 2008 Sep 12. 283(37):25150-63. pEGFP-C RND3 ARHE, Rho8, RhoE, memB Add to Cart
23230GFP-RhoHRhoH (Homo sapiens)Mammalian ExpressionRho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem. 2008 Sep 12. 283(37):25150-63. pEGFP-C RHOH ARHH, TTF Add to Cart
23231GFP-TCLTCL (Homo sapiens)Mammalian ExpressionRho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem. 2008 Sep 12. 283(37):25150-63. pEGFP-C RHOJ ARHJ, RASL7B, TC10B, TCL Add to Cart
23232GFP-TC10TC10 (Homo sapiens)Mammalian ExpressionRho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem. 2008 Sep 12. 283(37):25150-63. pEGFP-C RHOQ ARHQ, HEL-S-42, RASL7A, TC10, TC10A Add to Cart
23233GFP-RifRif (Homo sapiens)Mammalian ExpressionRho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem. 2008 Sep 12. 283(37):25150-63. pEGFP-C2 RHOF ARHF, RIF Add to Cart
23235GFP-hRhoDRhoD (Homo sapiens)Mammalian ExpressionRho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem. 2008 Sep 12. 283(37):25150-63. pcDNA3 RHOD ARHD, RHOHP1, RHOM, Rho Add to Cart
23236GFP-mRhoDRhoD (Mus musculus)Mammalian ExpressionRho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem. 2008 Sep 12. 283(37):25150-63. pEGFP Rhod AI326383, Arhd, Rho, RhoHP1, RhoM Add to Cart
23240GFP-pCdc42Cdc42 (Homo sapiens)Mammalian ExpressionRho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem. 2008 Sep 12. 283(37):25150-63. pEGFP-C CDC42 CDC42Hs, G25K, TKS Add to Cart
23241GFP-bCdc42Cdc42 (Homo sapiens)Mammalian ExpressionRho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem. 2008 Sep 12. 283(37):25150-63. pEGFP-C CDC42 CDC42Hs, G25K, TKS Add to Cart
53755pEGFP-C3-Sec3Sec3 (Homo sapiens)Mammalian ExpressionRal and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Mol Cell. 2014 Jan 23;53(2):209-20. doi: 10.1016/j.molcel.2013.12.004. Epub 2014 Jan 2. pEGFP-C3 plasmid that expresses Sec3 pEGFP-C3 EXOC1 BM-102, SEC3, SEC3L1, SEC3P Add to Cart
53756pEGFP-C3-Sec5Sec5 (Homo sapiens)Mammalian ExpressionRal and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Mol Cell. 2014 Jan 23;53(2):209-20. doi: 10.1016/j.molcel.2013.12.004. Epub 2014 Jan 2. pEGFP-C3 plasmid that expresses Sec5 pEGFP-C3 EXOC2 SEC5, SEC5L1, Sec5p Add to Cart
53757pEGFP-C3-Sec6Sec6 (Homo sapiens)Mammalian ExpressionRal and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Mol Cell. 2014 Jan 23;53(2):209-20. doi: 10.1016/j.molcel.2013.12.004. Epub 2014 Jan 2. pEGFP-C3 plasmid that expresses Sec6 pEGFP-C3 EXOC3 SEC6, SEC6L1, Sec6p Add to Cart
53758pEGFP-C3-Sec8Sec8 (Homo sapiens)Mammalian ExpressionRal and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Mol Cell. 2014 Jan 23;53(2):209-20. doi: 10.1016/j.molcel.2013.12.004. Epub 2014 Jan 2. pEGFP-C3 plasmid that expresses Sec8 pEGFP-C3 EXOC4 SEC8, SEC8L1, Sec8p Add to Cart
53759pEGFP-C3-Sec10Sec10 (Homo sapiens)Mammalian ExpressionRal and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Mol Cell. 2014 Jan 23;53(2):209-20. doi: 10.1016/j.molcel.2013.12.004. Epub 2014 Jan 2. pEGFP-C3 plasmid that expresses Sec10 pEGFP-C3 EXOC5 HSEC10, PRO1912, SEC10, SEC10L1, SEC10P Add to Cart
53760pEGFP-C3-Sec15Sec15 (Homo sapiens)Mammalian ExpressionRal and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Mol Cell. 2014 Jan 23;53(2):209-20. doi: 10.1016/j.molcel.2013.12.004. Epub 2014 Jan 2. pEGFP-C3 plasmid that expresses Sec15 pEGFP-C3 EXOC6 EXOC6A, SEC15, SEC15L, SEC15L1, SEC15L3, Sec15p Add to Cart
53761pEGFP-C3-Exo70Exo70 (Homo sapiens)Mammalian ExpressionRal and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Mol Cell. 2014 Jan 23;53(2):209-20. doi: 10.1016/j.molcel.2013.12.004. Epub 2014 Jan 2. pEGFP-C3 plasmid that expresses Exo70 pEGFP-C3 EXOC7 2-5-3p, EX070, EXO70, EXOC1, Exo70p, YJL085W Add to Cart
53762pEGFP-C3-Exo84Exo84 (Homo sapiens)Mammalian ExpressionRal and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Mol Cell. 2014 Jan 23;53(2):209-20. doi: 10.1016/j.molcel.2013.12.004. Epub 2014 Jan 2. pEGFP-C3 plasmid that expresses Exo84 pEGFP-C3 EXOC8 EXO84, Exo84p, SEC84 Add to Cart
58893pEGFP TEM4 FLTEM4 (Homo sapiens)Mammalian ExpressionIdentification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4. PLoS One. 2012;7(7):e41876. doi: 10.1371/journal.pone.0041876. Epub 2012 Jul 24. Expresses GFP tagged full length TEM4 protein pEGFP-C2 ARHGEF17 P164RHOGEF, TEM4, p164-RhoGEF Add to Cart
58894pEGFP TEM4 DEL NTERMTEM4 (Homo sapiens)Mammalian ExpressionIdentification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4. PLoS One. 2012;7(7):e41876. doi: 10.1371/journal.pone.0041876. Epub 2012 Jul 24. Expresses GFP tagged TEM4 with N terminus deleted pEGFP-C2 ARHGEF17 P164RHOGEF, TEM4, p164-RhoGEF Add to Cart
58895pEGFP TEM4 R130DTEM4 (Homo sapiens)Mammalian ExpressionIdentification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4. PLoS One. 2012;7(7):e41876. doi: 10.1371/journal.pone.0041876. Epub 2012 Jul 24. Expresses GFP Tagged full length TEM4 protein with R130D mutation pEGFP-C2 ARHGEF17 P164RHOGEF, TEM4, p164-RhoGEF Add to Cart
58896pEGFP TEM4 DEL 125-135TEM4 (Homo sapiens)Mammalian ExpressionIdentification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4. PLoS One. 2012;7(7):e41876. doi: 10.1371/journal.pone.0041876. Epub 2012 Jul 24. Expresses GFP tagged full length TEM4 protein with amino acids 125 - 135 deleted pEGFP-C2 ARHGEF17 P164RHOGEF, TEM4, p164-RhoGEF Add to Cart
58897p-super-retro puro RhoGDI2 shRNARhoGDI2 (Homo sapiens)Mammalian Expression, RNAiRhoGDI2 antagonizes ovarian carcinoma growth, invasion and metastasis. Small GTPases. 2011 Jul;2(4):202-210. Epub 2011 Jul 1. produces an shRNA against RhoGDI2 pSuper.retro.puro Add to Cart
58898pBabe-Kras G15AKRAS (Homo sapiens)Mammalian Expression, Retroviral Mutant Ras Constructs (unpublished) Expresses human Kras with a G15A mutation pBabe-puro KRAS C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, KI-RAS, KRAS1, KRAS2, NS, NS3, RALD, RASK2, c-Ki-ras2 Add to Cart
58899pBabe-Kras S17NKRAS (Homo sapiens)Mammalian Expression, Retroviral Mutant Ras Constructs (unpublished) Expresses human Kras with a S17N mutation pBabe-puro KRAS C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, KI-RAS, KRAS1, KRAS2, NS, NS3, RALD, RASK2, c-Ki-ras2 Add to Cart
58901pBabe-Kras G12CKRAS (Homo sapiens)Mammalian Expression, Retroviral Mutant Ras Constructs (unpublished) Expresses human Kras with a G12C mutation pBabe-puro KRAS C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, KI-RAS, KRAS1, KRAS2, NS, NS3, RALD, RASK2, c-Ki-ras2 Add to Cart
58902pBabe-Kras G12DKRAS (Homo sapiens)Mammalian Expression, Retroviral Mutant Ras Constructs (unpublished) Expresses human Kras with a G12D Mutation pBabe-puro KRAS C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, KI-RAS, KRAS1, KRAS2, NS, NS3, RALD, RASK2, c-Ki-ras2 Add to Cart
75282pBabe-Kras WtKRAS (Homo sapiens)Mammalian Expression, Retroviral Mutant Ras Constructs (unpublished) Expresses human Kras wild-type pBabe KRAS C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, KI-RAS, KRAS1, KRAS2, NS, NS3, RALD, RASK2, c-Ki-ras2 Add to Cart