Institute for Protein Innovation Antibody Collection

Welcome to the Institute for Protein Innovation (IPI) Collection!

Here, you’ll find unique recombinant antibodies targeting axonal guidance receptors and ligands (Glypicans and Integrins), components in the synapse (Neurexins and Neuroligins), and common epitope tags, as well as antibody plasmids to create or express plasmid-based antibodies.

Most antibodies in the collection have been developed using a platform based on yeast display technology and an optimized sorting process. This combination allows IPI to generate antibodies to highly conserved proteins and other difficult-to-target antigens that are intractable via animal immunization.

IPI is a nonprofit research organization with a mission to advance protein science to accelerate research and improve human health. As part of that mission, IPI is providing access to high-quality, well-characterized antibodies in an open science model.

Learn more about IPI

Axon Guidance

IPI’s Axon Guidance Antibody Collection comprises recombinant monoclonal antibodies with high specificity for critical axon guidance signaling proteins and growth cone receptors. Developed using yeast display technology, these antibodies enable high-confidence targeting of proteins that have historically been difficult to identify and interrogate with conventional reagents.

Figure 1: Axon guidance cues and receptors regulate the development of functional neural circuits at the growth cone. Image credit: IPI

Browse Netrin, DCC, and IGDCC3 (PUNC) Antibodies

Browse Glypican Antibodies

Glypicans are a family of highly conserved proteoglycans crucial for regulating cell signaling during development. The IPI collection includes anti-glypicans that accurately detect glypican presence and explore glypican function, providing a reliable and accessible toolset for scientists worldwide.

Synaptic Cleft

IPI’s Synaptic Cleft Antibody Collection features highly selective recombinant monoclonal antibodies targeting protein families that function at or across the synaptic cleft. Developed using yeast display technology, these antibodies provide researchers with powerful tools to investigate neurotransmission, synapse formation, neural connectivity, plasticity and neurological disorders.

The initial collection includes antibodies to Neurexin and Neuroligin receptor families, key mediators of synaptic adhesion and function. Additional antibodies targeting other synaptic cleft proteins are currently under development.

Figure 2: Key adhesion proteins and receptor–ligand pairs bridge the presynaptic and postsynaptic membranes at neuronal synapses. Image credit: IPI

Browse Neurexin and Neuroligin Antibodies

Integrins

Integrins are a family of mechanotransduction receptors, comprised of alpha-beta subunit heterodimers. The IPI collection contains antibodies that uniquely:

1. Bind to the alpha subunit, outside the ligand-binding pocket
2. Bind to the beta subunit, outside the ligand-binding pocket
3. Bind specific subunit pairs, outside the ligand-binding pocket
4. Bind specific subunit pairs, blocking ligand binding and receptor function

Figure 3: IPI Integrin antibodies exhibit distinct binding specificities — recognizing individual α or β subunits, or specific αβ subunit pairs — to block ligand interactions, disrupt integrin function, and/or detect integrin expression. Image credit: IPI

Browse Integrin Antibodies

Browse Epitope Tag Antibodies

IPI has developed recombinant versions of antibodies that recognize common epitope tags to help purify, detect, or localize particular proteins. Browse or search the table below to find antibodies targeting V5, Protein C, DYKDDDDK, Rho, His, Biotin, EE, GCN4 and Strep.

Please visit our Tags and Other Markers Antibody Collection page to browse Addgene’s full catalog of antibodies that target epitope tags and other common cellular proteins.

Browse Antibody Plasmids

The following plasmids can be used to create or express plasmid-based antibodies.