Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR.

Tzatsos A
J Biol Chem. 2009 Aug 21;284(34):22525-34. doi: 10.1074/jbc.M109.027748. Epub 2009 Jun 26. PubMed Article

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