AK-1, a SIRT2 inhibitor, destabilizes HIF-1alpha and diminishes its transcriptional activity during hypoxia.

Lee SD, Kim W, Jeong JW, Park JW, Kim JE
Cancer Lett. 2016 Jan 22. pii: S0304-3835(16)30001-5. doi: 10.1016/j.canlet.2016.01.031. PubMed Article

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