HPV16 E6 and E7 proteins induce a chronic oxidative stress response via NOX2 that causes genomic instability and increased susceptibility to DNA damage in head and neck cancer cells.

Marullo R, Werner E, Zhang H, Chen GZ, Shin DM, Doetsch PW
Carcinogenesis. 2015 Nov;36(11):1397-406. doi: 10.1093/carcin/bgv126. Epub 2015 Sep 8. PubMed Article

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