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Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents.

Sandhaus S, Annamalai T, Welmaker G, Houghten RA, Paz C, Garcia PK, Andres A, Narula G, Rodrigues Felix C, Geden S, Netherton M, Gupta R, Rohde KH, Giulianotti MA, Tse-Dinh YC
Antimicrob Agents Chemother. 2016 Jun 20;60(7):4028-36. doi: 10.1128/AAC.00288-16. Print 2016 Jul. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
249818pTA-M+Expresses Mycobacterium tuberculosis topoisomerase I under the control of the Tet promoter in mycobacteria
249819pTA-noIControl plasmid for null expression of recombinant protein when compared to pTA-M+ (see Table 1 of publication)

Antibodies from Article