The recombined cccDNA produced using minicircle technology mimicked HBV genome in structure and function closely.
Guo X, Chen P, Hou X, Xu W, Wang D, Wang TY, Zhang L, Zheng G, Gao ZL, He CY, Zhou B, Chen ZY
Sci Rep. 2016 May 13;6:25552. doi: 10.1038/srep25552.
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