The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway.
Carbonneau M, M Gagne L, Lalonde ME, Germain MA, Motorina A, Guiot MC, Secco B, Vincent EE, Tumber A, Hulea L, Bergeman J, Oppermann U, Jones RG, Laplante M, Topisirovic I, Petrecca K, Huot ME, Mallette FA
Nat Commun. 2016 Sep 14;7:12700. doi: 10.1038/ncomms12700.
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