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Studies on truncating mutations of SPAST associated with Hereditary Spastic Paraplegia indicate greater accumulation and toxicity of the M1 isoform of spastin.
Solowska JM, Rao AN, Baas PW
Mol Biol Cell. 2017 May 11. pii: mbc.E17-01-0047. doi: 10.1091/mbc.E17-01-0047.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
92365pCMV-Tag/M1 N184Xexpression of M1 N184X spastin in mammalian cells
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92366pCMV-Tag/M1 S245Xexpression of M1 S245X spastin in mammalian cells
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92367pCMV-Tag/M87 N184Xexpression of M87 N184X spastin in mammalian cells
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92368pCMV-Tag/M87 S245Xexpression of M87 S245X spastin in mammalian cells
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92370pCMV-Tag/SP S245X with 5'UTRexpression of 245X spastin M1 and M87 in mammalian cells
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92371pTRE/SP M1 N184XInducible expression of M1 N184X spastin in mammalian cells
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92372pTRE/SP M1 S245XInducible expression of M1S245X spastin in mammalian cells
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92373pTRE/SP M87 N184XInducible expression of M87 N184X spastin in mammalian cells
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92374pTRE/SP M87 S245XInducible expression of M87 S245X spastin in mammalian cells
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92375pTRE/SP N184X with 5'UTRInducible expression of N184X spastin M1 and M87 in mammalian cells
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92376pTRE/SP S245X with 5'UTRInducible expression of S245X spastin M1 and M87 in mammalian cells
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