Complete topology inversion can be part of normal membrane protein biogenesis.

Woodall NB, Hadley S, Yin Y, Bowie JU
Protein Sci. 2017 Apr;26(4):824-833. doi: 10.1002/pro.3131. Epub 2017 Feb 25. (Link opens in a new window) PubMed (Link opens in a new window) Article

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