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Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL-/- clear cell renal carcinoma.
Gao W, Li W, Xiao T, Liu XS, Kaelin WG Jr
Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1027-1032. doi: 10.1073/pnas.1619726114. Epub 2017 Jan 12.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
107399shPBRM1#32-Tet-pLKO-puroLentiviral expression of shRNA targeting PBRM
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107400shPBRM1#131-Tet-pLKO-puroLentiviral expression of shRNA targeting PBRM
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107401shPBRM1 #122-Tet-pLKO-puroLentiviral expression of shRNA targeting PBRM
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107402sgCtr- LentiCRISPRv2 Lentiviral expression of Cas9 and a control gRNA
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107403sgPBRM1-1- LentiCRISPRv2 Lentiviral expression of Cas9 and gRNA targeting PBRM1
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107404sgPBRM1-2- LentiCRISPRv2 Lentiviral expression of Cas9 and gRNA targeting PBRM1
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107406WT PBRM1- TRIPZ-neoMammalian expression, inducible PBRM1
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107407pLenti-PGK-Hygro-amp-sgRNA-resistant PBRM1Lentiviral expression of gRNA resistant PBRM1
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