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Continuous evolution of base editors with expanded target compatibility and improved activity.
Thuronyi BW, Koblan LW, Levy JM, Yeh WH, Zheng C, Newby GA, Wilson C, Bhaumik M, Shubina-Oleinik O, Holt JR, Liu DR
Nat Biotechnol. 2019 Jul 22. pii: 10.1038/s41587-019-0193-0. doi: 10.1038/s41587-019-0193-0.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
122595pBT2dR3-proB BE PACE selection, express T7 RNA polymerase with degron-GTCCA target
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122596pBT13-splitC clone M13 phage by SapI Golden Gate
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122597pBT13-splitD clone M13 phage by SapI Golden Gate
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122598pBT29-splitC clone M13 phage by SapI Golden Gate
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122599pBT29-splitD clone M13 phage by SapI Golden Gate
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122600pBT44c BE PACE selection, express C-intein-Cas9-ugi fusion
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122601pBT100.106b clone APOBEC1 phage by SapI Golden Gate
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122602pBT100.110 clone CDA1 phage by SapI Golden Gate
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122603pBT100.136c clone FERNY phage by SapI Golden Gate
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122604pBT120b BE PACE selection, express gIII, luxAB and degron-GTCCA guide RNA
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122605pBT137-splitC clone M13 phage by SapI Golden Gate
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122606pBT137-splitD clone M13 phage by SapI Golden Gate
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122607pBT276 express CDA1-BE4max in mammalian cells
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122608pBT277 express evoCDA1-BE4max in mammalian cells
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122609pBT279 express FERNY-BE4max in mammalian cells
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122610pBT280 express evoFERNY-BE4max in mammalian cells
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122611pBT281 express evoAPOBEC1-BE4max in mammalian cells
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125612pBT371Expresses CDA1-BE4max-NG in mammalian cells
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125613pBT372Expresses evoCDA1-BE4max-NG in mammalian cells
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125614pBT373Expresses FERNY-BE4max-NG in mammalian cells
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125615pBT374Expresses evoFERNY-BE4max-NG in mammalian cells
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125616pBT375Expresses evoAPOBEC1-BE4max-NG in mammalian cells
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125617pBT376Expresses BE4max-NG in mammalian cells
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127843pBT195clone BE4max CBEs by SapI Golden Gate
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127844pBT362clone BE4max-NG CBEs by SapI Golden Gate
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127845pBT271.359clone A3A CBEs by SapI Golden Gate
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127846pBT271.361clone A3A-W98Y CBEs by SapI Golden Gate
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