PTEN counteracts FBXL2 to promote IP3R3- and Ca(2+)-mediated apoptosis limiting tumour growth.
Kuchay S, Giorgi C, Simoneschi D, Pagan J, Missiroli S, Saraf A, Florens L, Washburn MP, Collazo-Lorduy A, Castillo-Martin M, Cordon-Cardo C, Sebti SM, Pinton P, Pagano M
Nature. 2017 Jun 22;546(7659):554-558. doi: 10.1038/nature22965. Epub 2017 Jun 14.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 236453 | pEGFPc1 IP3R3 WT | transient overexpression of IP3R3 in mammalian cells |
| 236454 | pEGFPc1 QFR IP3R3 | transient overexpression of IP3R3 in mammalian cells |
| 236455 | pcDNA3 FLAG FBXL2 | transient overexpression of FBXL2 in mammalian cells |
| 237340 | pEGFPc1 PTEN C124S | transient overexpression in mammalian cells |