A first-in-class inhibitor, MLN4924 (pevonedistat), induces cell-cycle arrest, senescence, and apoptosis in human renal cell carcinoma by suppressing UBE2M-dependent neddylation modification.

Xu B, Deng Y, Bi R, Guo H, Shu C, Shah NK, Chang J, Liu G, Du Y, Wei W, Wang C
Cancer Chemother Pharmacol. 2018 Jun;81(6):1083-1093. doi: 10.1007/s00280-018-3582-z. Epub 2018 Apr 17. PubMed Article

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