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CDK12 regulates DNA repair genes by suppressing intronic polyadenylation.
Dubbury SJ, Boutz PL, Sharp PA
Nature. 2018 Dec;564(7734):141-145. doi: 10.1038/s41586-018-0758-y. Epub 2018 Nov 28.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
127174Cdk12_intron3_sg2_pX330sgRNA that cuts within intron 3 of mouse Cdk12 genomic locus in pX330 backbone
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127175Cdk12_intron4_sg1_pX458sgRNA that cuts within intron 4 of mouse CDK12 genomic locus in pX458 backbone
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127176pCR8/GW_TOPO_Cdk12_UntaggedUntagged mouse Cdk12 transgene (NM_001109626.1 isoform) cloned into Gateway entry vector
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127177pCR8/GW_TOPO_Cdk12_Nterm_FlagHaN-terminal Flag- HA- tandem epitope tagged mouse Cdk12 transgene (NM_001109626.1 isoform) cloned into Gateway entry vector
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127178PB-Neo-TetO-Cdk12_UntaggedUntagged mouse Cdk12 transgene (NM_001109626.1 isoform) cloned into a dox-inducible piggybac destination vector
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127179PB-Neo-TetO-Cdk12_Nterm_FlagHaN-terminal Flag- HA- tandem epitope tagged mouse Cdk12 transgene (NM_001109626.1 isoform) cloned into a dox-inducible piggybac destination vector
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