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Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner.
O'Geen H, Bates SL, Carter SS, Nisson KA, Halmai J, Fink KD, Rhie SK, Farnham PJ, Segal DJ
Epigenetics Chromatin. 2019 May 3;12(1):26. doi: 10.1186/s13072-019-0275-8.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
126587DNMT3L-dCas9DNMT3L fused to N-terminus of dCas9; pCDNA3 vector backbone, mammalian expression
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126588dCas9-DNMT3LDNMT3L fused to C-terminus of dCas9; pCDNA3 vector backbone, mammalian expression
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126589NLS-HA-2xMCP-KRABExpresses MCP (MS2 Coat Protein) fusion to KRAB in mammalian cells, lentiviral backbone
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126590NLS-HA-2xMCP-Ezh2Expresses MCP (MS2 Coat Protein) fusion to Ezh2 in mammalian cells, lentiviral backbone
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Recombinant Antibodies from Article