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Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics.
Bedbrook CN, Yang KK, Robinson JE, Mackey ED, Gradinaru V, Arnold FH
Nat Methods. 2019 Oct 14. pii: 10.1038/s41592-019-0583-8. doi: 10.1038/s41592-019-0583-8. PubMed Article

Plasmids from Article

ID Plasmid Purpose  
127237pAAV-hSyn-ChRger2-TS-EYFPHigh photocurrent, low-light sensitive channelrhodopsin (ChRger2) for optogenetic activation with systemic delivery or for low-light activation. Driven by human Synapsin I promoter.
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127238pAAV-CaMKIIa-ChRger2-TS-EYFPHigh photocurrent, low-light sensitive channelrhodopsin (ChRger2) for optogenetic activation with systemic delivery or for low-light activation. Driven by the CamKIIa promoter.
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127239pAAV-CAG-DIO(ChRger2-TS-YFP)High photocurrent, low-light sensitive channelrhodopsin (ChRger2) for optogenetic activation with systemic delivery or for low-light activation. Driven by the CAG promoter and double floxed.
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127240pAAV-hSyn-ChRger3-TS-EYFPHigh photocurrent, low-light sensitive channelrhodopsin (ChRger3) for optogenetic activation with systemic delivery or for low-light activation. Driven by human Synapsin I promoter.
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127241pAAV-CaMKIIa-ChRger3-TS-EYFPHigh photocurrent, low-light sensitive channelrhodopsin (ChRger3) for optogenetic activation with systemic delivery or for low-light activation. Driven by the CamKIIa promoter.
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127242pAAV-CAG-DIO(ChRger3-TS-YFP)High photocurrent, low-light sensitive channelrhodopsin (ChRger3) for optogenetic activation with systemic delivery or for low-light activation. Driven by the CAG promoter and double floxed.
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127243pAAV-hSyn-ChRger1-TS-EYFPHigh photocurrent, low-light sensitive channelrhodopsin (ChRger1) for optogenetic activation with systemic delivery or for low-light activation. Driven by human Synapsin I promoter.
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127244pAAV-CaMKIIa-ChRger1-TS-EYFPHigh photocurrent, low-light sensitive channelrhodopsin (ChRger1) for optogenetic activation with systemic delivery or for low-light activation. Driven by the CamKIIa promoter.
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127245pAAV-CAG-DIO(ChRger1-TS-YFP)High photocurrent, low-light sensitive channelrhodopsin (ChRger1) for optogenetic activation with systemic delivery or for low-light activation. Driven by the CAG promoter and double floxed.
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129393pAAV-CaMKII-STChRger2-TS-EYFPSoma Targeted, High photocurrent, low-light sensitive channelrhodopsin (ChRger2) for optogenetic activation with systemic delivery or for low-light activation. Driven by the CamKIIa promoter.
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129394pAAV-CAG-DIO-(STChRger2-TS-EYFP)Soma Targeted, High photocurrent, low-light sensitive channelrhodopsin (ChRger2) for optogenetic activation with systemic delivery or for low-light activation. Uses the CAG promoter and double floxed.
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129395pAAV-hSyn-STChRger2-TS-EYFPSoma Targeted, High photocurrent, low-light sensitive channelrhodopsin (ChRger2) for optogenetic activation with systemic delivery or for low-light activation. Driven by human Synapsin I promoter.
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Recombinant Antibodies from Article