The receptor interaction region of Tyk2 contains a motif required for its nuclear localization.

Ragimbeau J, Dondi E, Vasserot A, Romero P, Uze G, Pellegrini S
J Biol Chem. 2001 Aug 17;276(33):30812-8. doi: 10.1074/jbc.M103559200. Epub 2001 Jun 8. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID	Plasmid	Purpose
139354	pEGFP-N3-TYK2	Expression of TYK2 protein fused with GFP
139355	pEGFP-N3-Myr-TYK2	Expression of membrane-anchored human TYK2 protein fused to GFP