Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death.

Jiang H, Xue X, Panda S, Kawale A, Hooy RM, Liang F, Sohn J, Sung P, Gekara NO
EMBO J. 2019 Oct 4;38(21):e102718. doi: 10.15252/embj.2019102718. Epub 2019 Sep 23. PubMed Article

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