A BAP1 synonymous mutation results in exon skipping, loss of function and worse patient prognosis.
Niersch J, Vega-Rubin-de-Celis S, Bazarna A, Mergener S, Jendrossek V, Siveke JT, Pena-Llopis S
iScience. 2021 Feb 12;24(3):102173. doi: 10.1016/j.isci.2021.102173. eCollection 2021 Mar 19. PubMed Article
Niersch J, Vega-Rubin-de-Celis S, Bazarna A, Mergener S, Jendrossek V, Siveke JT, Pena-Llopis S
iScience. 2021 Feb 12;24(3):102173. doi: 10.1016/j.isci.2021.102173. eCollection 2021 Mar 19. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 154020 | pBABE-hygro-BAP1-HA | Mammalian Expression of HA-tagged Wild-Type BAP1 |
| 154021 | pBABE-hygro-BAP1-C91S-HA | Mammalian Expression of HA-tagged p.C91S Mutant BAP1 |
| 154022 | pBABE-hygro-BAP1-G312G-HA | Mammalian Expression of HA-tagged BAP1 with the Synonymous Mutation p.G312G |
| 154023 | RG6-BAP1_E7 | Bichromatic Fluorescent Splicing Reporter Minigene for Wild-Type BAP1 Exon 7 |
| 154024 | RG6-BAP1_E7-D192D | Bichromatic Fluorescent Splicing Reporter Minigene for Mutant BAP1 Exon 7 c.576C>T, p.D192D (Synonymous Mutation) |
| 154025 | RG6-BAP1_E11 | Bichromatic Fluorescent Splicing Reporter Minigene for Wild-Type BAP1 Exon 11 |
| 154026 | RG6-BAP1_E11-G312G | Bichromatic Fluorescent Splicing Reporter Minigene for Mutant BAP1 Exon 11 c.936T>G, p.G312G (Synonymous Mutation) |