D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction.
Gobeil SM, Janowska K, McDowell S, Mansouri K, Parks R, Manne K, Stalls V, Kopp MF, Henderson R, Edwards RJ, Haynes BF, Acharya P
Cell Rep. 2021 Jan 12;34(2):108630. doi: 10.1016/j.celrep.2020.108630. Epub 2020 Dec 26. PubMed Article
Gobeil SM, Janowska K, McDowell S, Mansouri K, Parks R, Manne K, Stalls V, Kopp MF, Henderson R, Edwards RJ, Haynes BF, Acharya P
Cell Rep. 2021 Jan 12;34(2):108630. doi: 10.1016/j.celrep.2020.108630. Epub 2020 Dec 26. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 164565 | pαH-S-GSAS | SARS-CoV-2 Spike protein (S-GSAS variant) |
| 164566 | pαH-S-GSAS/D614G | SARS-CoV-2 Spike protein with D614G mutation (S-GSAS-D614G variant) |
| 164567 | pαH-S-HRV3C | SARS-CoV-2 Spike protein with furin site mutated to HRV3C site (S-HRV3C variant) |
| 164568 | pαH-S-HRV3C/D614G | SARS-CoV-2 Spike protein with furin site mutated to HRV3C site and D614G mutation (S-HRV3C-D614G variant) |
| 164569 | pαH-S-RRAR | SARS-CoV-2 Spike protein with Furin site restored (S-RRAR variant) |
| 164570 | pαH-S-RRAR/D614G | SARS-CoV-2 Spike protein with D614G mutation and Furin site restored (S-RRAR-D614G variant) |