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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease.
Lim CT, Tan KW, Wu M, Ulferts R, Armstrong LA, Ozono E, Drury LS, Milligan JC, Zeisner TU, Zeng J, Weissmann F, Canal B, Bineva-Todd G, Howell M, O'Reilly N, Beale R, Kulathu Y, Labib K, Diffley JFX
Biochem J. 2021 Jul 16;478(13):2517-2531. doi: 10.1042/BCJ20210244.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
169192pET11a_His-TEV-PLpro (nsp3) (SARS-CoV-2)To express SARS-CoV-2 Papain-like protease in E. coli
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169193pK27Sumo_His-SUMO-PLpro (nsp3) (SARS-CoV-2)To express SARS-CoV-2 Papain-like protease in E. coli
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169194pLIB_3xFlag-His-PLpro (nsp3) (SARS-CoV-2)Baculoviral transfer vector to express SARS-CoV-2 papain-like protease domain (nsp3) in insect cells
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169195pGEX4T1_GST-PLproCS-MBPTo express a PLpro substrate (GST-PLproCS-MBP) in E. coli
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Recombinant Antibodies from Article