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The metabolite alpha-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.

Zhang JY, Zhou B, Sun RY, Ai YL, Cheng K, Li FN, Wang BR, Liu FJ, Jiang ZH, Wang WJ, Zhou D, Chen HZ, Wu Q
Cell Res. 2021 Sep;31(9):980-997. doi: 10.1038/s41422-021-00506-9. Epub 2021 May 19. (Link opens in a new window) PubMed (Link opens in a new window) Article

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