ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.

Miao G, Zhao H, Li Y, Ji M, Chen Y, Shi Y, Bi Y, Wang P, Zhang H
Dev Cell. 2021 Feb 22;56(4):427-442.e5. doi: 10.1016/j.devcel.2020.12.010. Epub 2020 Dec 16. PubMed Article

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