The type II integral ER membrane protein VAP-B homolog in C. elegans is cleaved to release the N-terminal MSP domain to signal non-cell-autonomously.

Zein-Sabatto H, Cole T, Hoang HD, Tiwary E, Chang C, Miller MA
Dev Biol. 2021 Feb;470:10-20. doi: 10.1016/j.ydbio.2020.10.015. Epub 2020 Nov 5. PubMed Article

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