Glial reactivity and cognitive decline follow chronic heterochromatin loss in neurons.
Newman AG, Sharif J, Bessa P, Zaqout S, Brown JP, Richter D, Dannenberg R, Nakayama M, Mueller S, Schaub T, Manickaraj S, Boehm-Sturm P, Ohara O, Koseki H, Singh PB, Tarabykin V
Nat Commun. 2025 Aug 8;16(1):7325. doi: 10.1038/s41467-025-61319-7.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 179924 | pCAG-HP1α-eGFP | C terminal fusion of EGFP to mouse HP1α (Cbx5) |
| 179925 | pCAG-HP1β-eGFP | C terminal fusion of EGFP to mouse HP1β (Cbx1) |
| 179926 | pCAG-HP1γ-EGFP | C terminal fusion of EGFP to mouse HP1γ (Cbx3) |
| 179927 | pCAG-HP1γ-M158V-EGFP | C terminal fusion of EGFP to mouse HP1γ (Cbx3) containing M158V mutation |
| 179929 | pCAG-HP1γ-I165E-EGFP | C terminal fusion of EGFP to mouse HP1γ (Cbx3) containing I165E mutation |
| 179930 | pCAG-HP1γ-F167R-EGFP | C terminal fusion of EGFP to mouse HP1γ (Cbx3) containing F167R mutation |
| 179931 | pCAG-HP1γ-E170V-EGFP | C terminal fusion of EGFP to mouse HP1γ (Cbx3) containing E170V mutation |
| 179932 | pCAG-HP1γ-L172H-EGFP | C terminal fusion of EGFP to mouse HP1γ (Cbx3) containing L172H mutation |
| 179933 | pCAG-HP1γ-W174A-EGFP | C terminal fusion of EGFP to mouse HP1γ (Cbx3) containing W174A mutation |
| 179934 | pCAG-HP1γ-ΔCSD-EGFP | C terminal fusion of EGFP to mouse HP1γ (Cbx3) containing deletion of entire chromoshadow domain (ΔCSD) |
| 179936 | pCAG-HP1α-F44E-EGFP | C terminal fusion of EGFP to mouse HP1α (Cbx5) containing F44E mutation |
| 179937 | pCAG-HP1α-I165E-EGFP | C terminal fusion of GFP to mouse HP1α (Cbx5) containing I165E mutation |
| 179938 | pCAG-HP1β-F45E-EGFP | C terminal fusion of EGFP to mouse HP1β (Cbx1) containing F45E mutation |
| 179939 | pCAG-HP1β-I161E-EGFP | C terminal fusion of EGFP to mouse HP1β (Cbx1) containing I161E mutation |