TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.
Wang Y, Su L, Morin MD, Jones BT, Whitby LR, Surakattula MM, Huang H, Shi H, Choi JH, Wang KW, Moresco EM, Berger M, Zhan X, Zhang H, Boger DL, Beutler B
Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E884-93. doi: 10.1073/pnas.1525639113. Epub 2016 Feb 1.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 187877 | pAcGP67A-mTLR4ecd-VLR | Baculovirus protein expression of mouse TLR4 (residues 26–544) fused with hagfish variable lymphocyte receptor (VLR) (residues 126–200) |
| 187878 | pAcGP67A-mMD2-proA | baculovirus protein expression of mouse MD-2 (residues 19–160) fused to a protein A tag |