Morphine acts on spinal dynorphin neurons to cause itch through disinhibition.

Nguyen E, Lim G, Ding H, Hachisuka J, Ko MC, Ross SE
Sci Transl Med. 2021 Feb 3;13(579). pii: 13/579/eabc3774. doi: 10.1126/scitranslmed.abc3774. PubMed Article

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