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A multiplexed in vivo approach to identify driver genes in small cell lung cancer.
Lee MC, Cai H, Murray CW, Li C, Shue YT, Andrejka L, He AL, Holzem AME, Drainas AP, Ko JH, Coles GL, Kong C, Zhu S, Zhu C, Wang J, van de Rijn M, Petrov DA, Winslow MM, Sage J
Cell Rep. 2023 Jan 13;42(1):111990. doi: 10.1016/j.celrep.2023.111990. PubMed Article

Plasmids from Article

ID Plasmid Purpose
193198Lenti-EFS-EGFP-T2A-BsdLentiviral vector expressing EGFP (driven by EFS promoter) and a blasticidin resistance marker
193199Lenti-EFS-hTSC1-T2A-BsdLentiviral vector expressing human TSC1 cDNA (driven by EFS promoter) and a blasticidin resistance marker
193200Lenti-sgAdgb#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Adgb gene
193201Lenti-sgAdgb#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Adgb gene
193202Lenti-sgApc#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Apc gene
193203Lenti-sgBrip1#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Brip1 gene
193204Lenti-sgBrip1#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Brip1 gene
193205Lenti-sgCol11a1#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Col11a1 gene
193206Lenti-sgCol11a1#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Col11a1 gene
193207Lenti-sgCol22a1#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Col22a1 gene
193208Lenti-sgCol22a1#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Col22a1 gene
193209Lenti-sgCrebbp#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Crebbp gene
193210Lenti-sgCrebbp#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Crebbp gene
193211Lenti-sgErich3#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Erich3 gene
193212Lenti-sgErich3#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Erich3 gene
193213Lenti-sgFam135b#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Fam135b gene
193214Lenti-sgFam135b#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Fam135b gene
193215Lenti-sgFlt4#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Flt4 gene
193216Lenti-sgFlt4#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Flt4 gene
193217Lenti-sgGrin2a#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Grin2a gene
193218Lenti-sgHcn1#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Hcn1 gene
193219Lenti-sgMroh2b#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Mroh2b gene
193220Lenti-sgMroh2b#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Mroh2b gene
193221Lenti-sgNkx2-1#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Nkx2-1 gene
193222Lenti-sgNkx2-1#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Nkx2-1 gene
193223Lenti-sgNotch1#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Notch1 gene
193224Lenti-sgNotch1#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Notch1 gene
193225Lenti-sgNotch2#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Notch2 gene
193226Lenti-sgNotch2#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Notch2 gene
193227Lenti-sgNotch3#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Notch3 gene
193228Lenti-sgNotch3#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Notch3 gene
193229Lenti-sgPcdh15#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Pcdh15 gene
193230Lenti-sgPcdh15#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Pcdh15 gene
193231Lenti-sgPrdm9#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Prdm9 gene
193232Lenti-sgPrdm9#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Prdm9 gene
193233Lenti-sgRos1#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Ros1 gene
193234Lenti-sgRos1#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Ros1 gene
193235Lenti-sgRunx1t1#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Runx1t1 gene
193236Lenti-sgRunx1t1#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Runx1t1 gene
193237Lenti-sgSis#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Sis gene
193238Lenti-sgSis#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Sis gene
193239Lenti-sgSpen#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Spen gene
193240Lenti-sgSpen#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Spen gene
193241Lenti-sgSphkap#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Sphkap gene
193242Lenti-sgTmem132d#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Tmem132d gene
193243Lenti-sgTmem132d#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Tmem132d gene
193244Lenti-sgTnr#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Tnr gene
193245Lenti-sgTnr#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Tnr gene
193246Lenti-sgTsc1#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Tsc1 gene
193247Lenti-sgTsc1#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Tsc1 gene
193248Lenti-sgZfp536#1/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Zfp536 gene
193249Lenti-sgZfp536#2/CreLentiviral vector expressing Cre recombinase (driven by mPGK promoter) and an sgRNA against the mouse Zfp536 gene

Antibodies from Article