Is spastic ataxia 8 a protein misfolding disorder?
Ferreira-Peralta P, Franca B, Murtinheira F, Rodrigues MS, Herrera F
Biochim Biophys Acta Mol Basis Dis. 2023 Sep 9;1870(1):166882. doi: 10.1016/j.bbadis.2023.166882.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 203712 | pcDNA3.1 NKX6-2-Venus | Constitutive mammaliam expression of human NKX6-2 cDNA fused with the Venus fluorescent protein |
| 203713 | pcDNA3.1 NKX6-2(1-40)-Venus | SPAX8-related truncated mutation (K41*) containing the amino acids 1 to 40 of human NKX6-2, fused with the Venus fluorescent protein. |
| 203714 | pcDNA3.1 NKX6-2(1-188)-Venus | SPAX8-related truncated mutation (E189*) containing the amino acids 1 to 188 of human NKX6-2 fused with the Venus fluorescent protein |
| 203715 | pcDNA3.1 NKX6-2-Venus S246A | human NKX6-2 S246A phosphoresistant mutant |
| 203716 | pcDNA3.1 NKX6-2-Venus S246D | human NKX6-2 S246D phosphomimic mutant |
| 203717 | pcDNA3.1 NKX6-2-Venus T252A | human NKX6-2 T252A phosphoresistant mutant |
| 203718 | pcDNA3.1 NKX6-2-Venus T252D | human NKX6-2 T252D phosphomimic mutant |
| 209178 | pcDNA3.1 NKX6-2-Venus L163V | Mammalian expression of SPAX8-related missense mutation (L163V) in human NKX6-2 fused with the Venus fluorescent protein |
| 209179 | pcDNA3.1 NKX6-2-Venus R200W | Mammalian expression of SPAX8-related missense mutation (R200W) in human NKX6-2 fused with the Venus fluorescent protein |
| 209180 | pcDNA3.1 NKX6-2-Venus S246A/T252A | Mammalian expression of human NKX6-2 T252D phosphoresistant mutant |
| 209181 | pcDNA3.1 NKX6-2-Venus Y238F | Mammalian expression of human NKX6-2 T252D phosphoresistant mutant |
| 209182 | pcDNA3.1 NKX6-2(1-196)-Venus | Mammalian expression of human NKX6-2 cDNA SPAX8-related truncated mutation containing the amino acids 1 to 196; fused with the green fluorescent protein Venus allowing the use of fluorescent based protocols. |