RUNX1 isoform disequilibrium promotes the development of trisomy 21-associated myeloid leukemia.
Gialesaki S, Brauer-Hartmann D, Issa H, Bhayadia R, Alejo-Valle O, Verboon L, Schmell AL, Laszig S, Regenyi E, Schuschel K, Labuhn M, Ng M, Winkler R, Ihling C, Sinz A, Glass M, Huttelmaier S, Matzk S, Schmid L, Struwe FJ, Kadel SK, Reinhardt D, Yaspo ML, Heckl D, Klusmann JH
Blood. 2023 Mar 9;141(10):1105-1118. doi: 10.1182/blood.2022017619.
(Link opens in a new window)
PubMed
(Link opens in a new window)
Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 181976 | pLeGO.sgGata1.4.RUNX1A.iG2 | gene knock out of mouse GATA1, overexpression of 3xFLAG-RUNX1A (human) |
| 181977 | SIN40C.TRE.HA.RUNX1A.IRES.dTomato.PGK.sfGFP.P2A.Tet3G | Human RUNX1A gene overexpression |
| 181978 | SIN40C.TRE.HA.RUNX1C.IRES.dTomato.PGK.sfGFP.P2A.Tet3G | Human RUNX1C gene overexpression |
| 181979 | pRRL.PPT.SFFV.HA.RUNX1A.IRES.eGFP | Human RUNX1A gene overexpression |
| 181980 | pRRL.PPT.SFFV.HA.RUNX1C.IRES.eGFP | Human RUNX1C gene overexpression |
| 181981 | pLKO5d.SFFV.Cas9.P2A.BSD | Lentiviral Cas9 expression |
| 187191 | pLKO5d.SFFV.IRES.dTomato | Lentiviral gene overexpression (backbone/control) |
| 187192 | pLKO5d.SFFV.Cre.IRES.dTomato | Lentiviral overexpression of Cre recombinase |