Mitochondrial Ca(2+) efflux controls neuronal metabolism and long-term memory across species.
Amrapali Vishwanath A, Comyn T, Mira RG, Brossier C, Pascual-Caro C, Faour M, Boumendil K, Chintaluri C, Ramon-Duaso C, Fan R, Ghosh K, Farrants H, Berwick JP, Sivakumar R, Lopez-Manzaneda M, Schreiter ER, Preat T, Vogels TP, Rangaraju V, Busquets-Garcia A, Placais PY, Pavlowsky A, de Juan-Sanz J
Nat Metab. 2026 Feb 11. doi: 10.1038/s42255-026-01451-w.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 212660 | CamKII-mito4x-GCaMP6f-IRES2-MCS | Expresses under a CamKII promoter: mito4x-GCaMP6f and a multiple cloning site (MCS) after an IRES sequence |
| 212661 | CamKII-mito4x-GCaMP6f-IRES2-rat-Letm1 | Expresses under a CamKII promoter: mito4x-GCaMP6f and rat-Letm1 |
| 212662 | CamKII-mito4x- GCaMP6f-IRES2-rat-Letm1-ΔEFhand | Expresses under a CamKII promoter: mito4x-GCaMP6f and rat-Letm1 with mutations in its EF-hand |
| 212663 | CamKII-mito4x-GCaMP6f-Drosophila-Letm1 | Expresses under a CamKII promoter: mito4x-GCaMP6f and Drosophila-Letm1 |
| 214404 | pAAV-Camk2a(short)-mRFP1.Letm1[miR30-shRNA]-WPRE | Expresses a mouse Letm1 specific microRNA in tandem with mRFP1 |
| 214405 | pAAV-Camk2a(short)-mRFP.Scramble[miR30-shRNA]-WPRE | Expresses a control non-specific microRNA in tandem with mRFP1 |
| 215362 | pLKO-U6-Letm1shRNA-hPGK-Puro | Expresses a rat Letm1 specific shRNA |
| 215363 | pLKO-U6-Letm1shRNA-hPGK-mTagBFP2 | Expresses a rat Letm1 specific shRNA and a BFP under a separate hPGK promoter |
| 215365 | pLKO-U6-Letm1shRNA-hPGK-miRFPnano | Expresses a rat Letm1 specific shRNA and miRFPnano under a separate hPGK promoter |
| 243810 | Mito4x-LA-GCaMP6s | Expresses a low affinity (LA) calcium sensor directed to the mitochondrial matrix |