Loss of KDEL function from a calreticulin frameshift mutation drives expression of an immature, mutant calreticulin-dependent form of the thrombopoietin receptor MPL.
Masubuchi N, Yang Y, Imai M, Kihara Y, Morishita S, Edahiro Y, Komatsu N
Haematologica. 2025 Nov 6. doi: 10.3324/haematol.2025.287585.
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Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 214784 | pMSCV-IRES-GFP/CALR del52-KDEL | Mammalian expression of human CALR del52-KDEL |
| 214785 | pMSCV-IRES-GFP/CALR ins5-KDEL | Mammalian expression of human CALR ins5-KDEL |
| 214786 | pMSCV/CALR del52-linker-Venus-KDEL | Mammalian expression of human del52-linker-Venus-KDEL |
| 214787 | pMSCV/CALR ins5-linker-Venus-KDEL | Mammalian expression of human CALR ins5-linker-Venus-KDEL |
| 214788 | pMSCV/CALR del52-linker-Venus | Mammalian expression of human CALR del52-linker-Venus |
| 214789 | pMSCV/CALR ins5-linker-Venus | Mammalian expression of human CALR ins5 -linker-Venus |
| 214790 | pcDNA3.1/CALR WTΔKDEL | Mammalian expression of human CALR wtΔKDEL |
| 214791 | pMSCV-IRES-GFP/CALR wtΔKDEL | Mammalian expression of human CALR wtΔKDEL |
| 214792 | pcDNA3.1/CALR wtΔKDEL-FLAG-KDEL | Mammalian expression of human CALR wtΔKDEL-FLAG-KDEL |
| 214793 | pMSCV-IRES-DsRed/MPL | Mammalian expression of human MPL |
| 214794 | pcDNA3.1/MPL-V5 | Mammalian expression of human MPL-V5 |
| 214795 | pFastBac1/CALR del52-His | Baculovirus expression of human CALR del52-His |
| 214796 | pFastBac1/CALR ins5-His | Baculovirus expression of human CALR ins5 |
| 214797 | pcDNA3.1/CALR wt | Mammalian expression of human CALR wt |
| 214798 | pcDNA3.1/CALR del52 | Mammalian expression of human CALR del52 |
| 214799 | pcDNA3.1/CALR ins5 | Mammalian expression of human CALR ins5 |
| 214800 | pcDNA3.1/MPL(N117Q) | Mammalian expression of human MPL(N117Q) |
| 214801 | pcDNA3.1/MPL(N178Q) | Mammalian expression of human MPL(N178Q) |
| 214802 | pcDNA3.1/MPL(N298Q) | Mammalian expression of human MPL(N298Q) |
| 214803 | pcDNA3.1/MPL(N358Q) | Mammalian expression of human MPL(N358Q) |
| 214804 | pcDNA3.1/MPL(N178/298/358Q) | Mammalian expression of human MPL(N178/298/358Q) |
| 214805 | pcDNA3.1/CALR wtΔKDEL YD/FL | Mammalian expression of human CALR wtΔKDEL YD/FL |