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Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas.

Cheung JF, Hunt BG, Wahed S, Cheng E, Connolly KA, Venkatesan S, Loza JL, Bansal I, Fagerberg E, Kessler EA, Riffard C, Buck J, Attanasio J, Borr ER, Wei W, William I, Fitzgerald B, Joshi NS
Cancer Cell. 2025 Oct 2:S1535-6108(25)00397-6. doi: 10.1016/j.ccell.2025.09.005. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
216481LV-pCMV-FLPo-pGK-mCl-GP33/66Expresses FLPo and mClover3 fluorescent protein with LMCV GP33-43 and GP66-77 epitopes embedded in loop of mclover to initiate immunogenic tumor cells in KPFrt mice
216482pLox-LV-pCMV-FLPo-pGK-mCl-GP33/66Expresses a lox-p flanked FLPo and mClover3 fluorescent protein with LMCV GP33-43 and GP66-77 epitopes embedded in loop of mclover for initiating and removing immunogenic tumor cells in KPFrt mice

Antibodies from Article