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Addgene
Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication.
Zeng J, Hills SA, Ozono E, Diffley JFX
Cell. 2023 Feb 2;186(3):528-542.e14. doi: 10.1016/j.cell.2022.12.036. Epub 2023 Jan 20. PubMed Article

Plasmids from Article

ID Plasmid Purpose
216508pcDNA4/TO-cyclin EExpresses cyclin E1 in human cells under a tetracycline/doxycycline-inducible promoter
216509pcDNA4/TO-HRASG12VExpresses HRAS with a G12V point mutation in human cells under a tetracycline/doxycycline-inducible promoter
216510pcDNA4/TO-cMYCExpresses MYC in human cells under a tetracycline/doxycycline-inducible promoter
216511pcDNA4/TO-CDC25AExpresses CDC25A in human cells under a tetracycline/doxycycline-inducible promoter
217455PX459-TP53-exon4For TP53 knockout targeting exon 4 of TP53
217456PX459-TP53-exon5For TP53 knockout targeting exon 5 of TP53
217457PX459-CDKN1AFor CDKN1A (p21) knockout

Antibodies from Article