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AAV-compatible optogenetic tools for activating endogenous calcium channels in vivo.

Kook YH, Lee H, Lee J, Jeong Y, Rho J, Heo WD, Lee S
Mol Brain. 2023 Oct 17;16(1):73. doi: 10.1186/s13041-023-01061-7. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
248293pCMV-FLAG-CRY2-STIM1(238-685)An expression construct encoding a CRY2-fused FLAG-tagged STIM1 fragment (a.a.238–685).
248294pCMV-EGFP-CRY2-STIM1(318-450)An expression construct encoding a CRY2-fused truncated STIM1 fragment (a.a.318–450).
248295pCMV-EGFP-IRES2-CRY2-STIM1(238-448)An expression construct encoding a CRY2-fused STIM1 fragment (a.a.238-448) linked to EGFP through an IRES2 element.
248296pCMV-CIBN-STIM1(238-685)An expression construct encoding a CIBN-fused STIM1 fragment (a.a.238-685).
248297pCMV-EGFP-STIM1(238-685)An expression construct encoding an EGFP-fused STIM1 fragment (a.a.238-685).
248298pCMV-vhhGFP-CRY2An expression construct encoding a GFP nanobody (vhhGFP) fused to CRY2.
248299pAAV-CaMKIIα-FLAG-STIM1(238-685)An AAV construct designed to express a CRY2-fused FLAG-tagged STIM1 fragment (a.a.238-685) under the control of the CaMKIIα promoter.
248301pAAV-GfaABC1D-FLAG-STIM1(238-685)An AAV construct designed to express a CRY2-fused FLAG-tagged STIM1 fragment (a.a.238-685) under the control of the GfaABC1D promoter.
248302pAAV-GfaABC1D-EGFP-CRY2-STIM1(318-450)An AAV construct designed to express a CRY2-fused truncated STIM1 fragment (a.a.318–450) under the control of the GfaABC1D promoter.

Antibodies from Article