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IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus.

Guney MH, Nagalekshmi K, McCauley SM, Carbone C, Aydemir O, Luban J
Proc Natl Acad Sci U S A. 2024 Jul 16;121(29):e2404349121. doi: 10.1073/pnas.2404349121. Epub 2024 Jul 10. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
174221pPU-HSA-miR30-L1221All-in-one control rescue-control shRNA knockdown vector
174222pPU-HSA-miR30-MDA5All-in-one control rescue-MDA5 shRNA knockdown vector
174223pPU-huMDA5-miR30-L1221All-in-one huMDA5 rescue-control shRNA knockdown vector
174224pPU-huMDA5-miR30-MDA5All-in-one huMDA5 rescue-MDA5 shRNA knockdown vector
174225pscALPSpuro-MDA5delta2CARDExpresses human MDA5 that lacks 2 CARD domains
174226pscALPSpuro-MDA5-S88DExpresses human MDA5 S88D mutant
174227pscALPSpuro-MDA5-S88EExpresses human MDA5 S88E mutant
174228pscALPSpuro-Nipah VExpresses Nipah virus V
174229pAPM-miR30-CAPRIN1-ts1CAPRIN1 knockdown
174230pAPM-miR30-CAPRIN1-ts2CAPRIN1 knockdown
174231pAPM-miR30-CAPRIN1-ts3CAPRIN1 knockdown
174232pAPM-miR30-DDX1-ts1DDX1 knockdown
174233pAPM-miR30-DDX1-ts2DDX1 knockdown
174234pAPM-miR30-DDX1-ts3DDX1 knockdown
174235pAPM-miR30-DDX3X-ts1DDX3X knockdown
174236pAPM-miR30-DDX3X-ts2DDX3X knockdown
174237pAPM-miR30-DDX3X-ts3DDX3X knockdown
174238pAPM-miR30-DDX17-ts1DDX17 knockdown
174239pAPM-miR30-DDX17-ts2DDX17 knockdown
174240pAPM-miR30-DDX17-ts3DDX17 knockdown
174241pAPM-miR30-DDX58-ts1DDX58 knockdown
174242pAPM-miR30-DDX58-ts2DDX58 knockdown
174243pAPM-miR30-DDX58-ts3DDX58 knockdown
174244pAPM-miR30-DHX58-ts1DHX58 knockdown
174245pAPM-miR30-DHX58-ts2DHX58 knockdown
174246pAPM-miR30-DHX58-ts3DHX58 knockdown
174247pAPM-miR30-EIF2AK2-ts1EIF2AK2 knockdown
174248pAPM-miR30-EIF2AK2-ts2EIF2AK2 knockdown
174249pAPM-miR30-EIF2AK2-ts3EIF2AK2 knockdown
174250pAPM-miR30-HNRNPK-ts1HNRNPK knockdown
174251pAPM-miR30-HNRNPK-ts2HNRNPK knockdown
174252pAPM-miR30-HNRNPK-ts3HNRNPK knockdown
174253pAPM-miR30-HNRNPR-ts1HNRNPR knockdown
174254pAPM-miR30-HNRNPR-ts2HNRNPR knockdown
174255pAPM-miR30-HNRNPR-ts3HNRNPR knockdown
174256pAPM-miR30-IFI16-ts1IFI16 knockdown
174257pAPM-miR30-IFI16-ts2IFI16 knockdown
174258pAPM-miR30-IFI16-ts3IFI16 knockdown
174259pAPM-miR30-IFIH1-ts1IFIH1 knockdown
174260pAPM-miR30-IFIH1-ts2IFIH1 knockdown
174261pAPM-miR30-IFIH1-ts3IFIH1 knockdown
174262pAPM-miR30-ILF2-ts1ILF2 knockdown
174263pAPM-miR30-ILF2-ts2ILF2 knockdown
174264pAPM-miR30-ILF2-ts3ILF2 knockdown
174265pAPM-miR30-ILF3-ts1ILF3 knockdown
174266pAPM-miR30-ILF3-ts2ILF3 knockdown
174267pAPM-miR30-ILF3-ts3ILF3 knockdown
174268pAPM-miR30-LRPPRC-ts1LRPPRC knockdown
174269pAPM-miR30-LRPPRC-ts2LRPPRC knockdown
174270pAPM-miR30-LRPPRC-ts3LRPPRC knockdown
174271pAPM-miR30-MATR3-ts1MATR3 knockdown
174272pAPM-miR30-MATR3-ts2MATR3 knockdown
174273pAPM-miR30-MATR3-ts3MATR3 knockdown
174274pAPM-miR30-MAVS-ts1MAVS knockdown
174275pAPM-miR30-MAVS-ts2MAVS knockdown
174276pAPM-miR30-MAVS-ts3MAVS knockdown
174277pAPM-miR30-MOV10-ts1MOV10 knockdown
174278pAPM-miR30-MOV10-ts2MOV10 knockdown
174279pAPM-miR30-MOV10-ts3MOV10 knockdown
174280pAPM-miR30-MYD88-ts1MYD88 knockdown
174281pAPM-miR30-MYD88-ts2MYD88 knockdown
174282pAPM-miR30-MYD88-ts3MYD88 knockdown
174283pAPM-miR30-TMEM173-ts1TMEM173 knockdown
174284pAPM-miR30-TMEM173-ts2TMEM173 knockdown
174285pAPM-miR30-TMEM173-ts3TMEM173 knockdown
174286pAPM-miR30-XPO1-ts1XPO1 knockdown
174287pAPM-miR30-XPO1-ts2XPO1 knockdown
174288pAPM-miR30-XPO1-ts3XPO1 knockdown
174289pAPM-miR30-ZC3HAV1-ts1ZC3HAV1 knockdown
174290pAPM-miR30-ZC3HAV1-ts2ZC3HAV1 knockdown
174291pAPM-miR30-ZC3HAV1-ts3ZC3HAV1 knockdown

Antibodies from Article