PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Seif-El-Dahan M, Kefala-Stavridi A, Frit P, Hardwick SW, Chirgadze DY, Maia De Oliviera T, Andreani J, Britton S, Barboule N, Bossaert M, Pandurangan AP, Meek K, Blundell TL, Ropars V, Calsou P, Charbonnier JB, Chaplin AK
Sci Adv. 2023 Jun 2;9(22):eadg2834. doi: 10.1126/sciadv.adg2834. Epub 2023 May 31.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 257236 | pCAG-eSpCas9-2A-GFP-sgRNA-PAXX | To generate PAXX KO in human cells. Co-expresses eSpCas9(1.1), GFP and a guide RNA against PAXX exon 2. |
| 257237 | pCAG-eSpCas9-2A-GFP-sgRNA-XLF | To generate XLF KO in human cells. Co-expresses eSpCas9(1.1), GFP and a guide RNA against XLF exon 3. |