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Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH.
Gahlot P, Kravic B, Rota G, van den Boom J, Levantovsky S, Schulze N, Maspero E, Polo S, Behrends C, Meyer H
Mol Cell. 2024 Mar 14:S1097-2765(24)00172-2. doi: 10.1016/j.molcel.2024.02.029. PubMed Article

Plasmids from Article

ID Plasmid Purpose
218578peGFP C3-SPG20Expresses GFP-tagged human SPG20 in mammalian cells
218579peGFP C3-SPG20 8xVExpresses GFP-tagged human SPG20 bulky hydrophobic amino acid mutant in mammalian cells
218580peGFP C1-SPG20 SC domainExpresses GFP-tagged SC domain of human SPG20 in mammalian cells
218581peGFP C3-SPG20-PAAAExpresses GFP-tagged PPAY motif mutant (PAAA) of human SPG20 in mammalian cells; this mutant does not interact with ITCH
218582peGFP C2-IST1Expresses GFP-tagged human IST1 in mammalian cells

Antibodies from Article