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Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque.

Kussick E, Johansen N, Taskin N, Chowdhury A, Quinlan MA, Fraser A, Clark AG, Wynalda B, Martinez R, Groce EL, Reding M, Liang E, Shulga L, Huang C, Casper T, Clark M, Ho W, Gao Y, van Velthoven CTJ, Sobieski C, Ferrer R, Berg MR, Curtis BC, English C, Day JC, Fortuna MG, Donadio N, Newman D, Yao S, Chakka AB, Goldy J, Torkelson A, Guzman JB, Chakrabarty R, Nguy B, Guilford N, Pham TH, Wright V, Ronellenfitch K, Naidoo R, Kenney J, Williford A, Ramakrishnan C, Drinnenberg A, Gudsnuk K, Thyagarajan B, Smith KA, Dee N, Deisseroth K, Zeng H, Yao Z, Tasic B, Levi BP, Hodge R, Bakken TE, Lein ES, Ting JT, Daigle TL
Cell Rep. 2025 Jun 24;44(6):115730. doi: 10.1016/j.celrep.2025.115730. Epub 2025 May 21. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
223900HCT1_rAAV-eHGT_1137m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223901HCT2_rAAV-eHGT_1138m-minBglobin-SYFP2-WPRE3-BGHpA Direct-expressing SYFP2 AAV virus
223902HCT3_rAAV-eHGT_1139m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223903HCT4_rAAV-eHGT_1140m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223904HCT6_rAAV-eHGT_1141m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223905HCT7_rAAV-eHGT_1142m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223906HCT8_rAAV-eHGT_1143m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223908HCT10_rAAV-eHGT_1145m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223910HCT12_rAAV-eHGT_1049m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223911HCT13_rAAV-eHGT_1050m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223912HCT14_rAAV-eHGT_1051m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223913HCT15_rAAV-eHGT_1052m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223915HCT33_rAAV-eHGT_1159m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223916HCT39_rAAV-eHGT_1181m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223917HCT40_rAAV-eHGT_1182m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223918HCT41_rAAV-eHGT_1183m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223919HCT42_rAAV-eHGT_1184m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223920HCT43_rAAV-eHGT_1185m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223921HCT75_rAAV-eHGT_1302m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223923HCT77_rAAV-eHGT_1304m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223924HCT79_rAAV-eHGT_1306m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223925HCT80_rAAV-eHGT_1307m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223926HCT81_rAAV-eHGT_1308m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223928HCT128_rAAV-eHGT_1495m-minBglobin-SYFP2-WPRE3-BGHpA Direct-expressing SYFP2 AAV virus
223929HCT129_rAAV-eHGT_1496m-minBglobin-SYFP2-WPRE3-BGHpA Direct-expressing SYFP2 AAV virus
223930HCT130_rAAV-eHGT_1497m-minBglobin-SYFP2-WPRE3-BGHpA Direct-expressing SYFP2 AAV virus
223931HCT131_rAAV-eHGT_1498m-minBglobin-SYFP2-WPRE3-BGHpA Direct-expressing SYFP2 AAV virus
223932HCT132_rAAV-eHGT_1499m-minBglobin-SYFP2-WPRE3-BGHpA Direct-expressing SYFP2 AAV virus
223933HCT133_rAAV-eHGT_1500m-minBglobin-SYFP2-WPRE3-BGHpA Direct-expressing SYFP2 AAV virus
223934HCT134_rAAV-eHGT_1501m-minBglobin-SYFP2-WPRE3-BGHpA Direct-expressing SYFP2 AAV virus
223935HCT135_rAAV-eHGT_1502m-minBglobin-SYFP2-WPRE3-BGHpA Direct-expressing SYFP2 AAV virus
223936HCT136_rAAV-eHGT_1503m-minBglobin-SYFP2-WPRE3-BGHpA Direct-expressing SYFP2 AAV virus
223938HCT138_rAAV-eHGT_1505m-minBglobin-SYFP2-WPRE3-BGHpA Direct-expressing SYFP2 AAV virus
223939HCT139_rAAV-eHGT_1506m-minBglobin-SYFP2-WPRE3-BGHpA Direct-expressing SYFP2 AAV virus
223940HCT140_rAAV-eHGT_1507m-minBglobin-SYFP2-WPRE3-BGHpA Direct-expressing SYFP2 AAV virus
223941HCT44_rAAV-eHGT_1186m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223942HCT45_rAAV-eHGT_1187m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223943HCT46_rAAV-eHGT_1188m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223944HCT49_rAAV-3Xcore-eHGT_1139m-minBglobin-SYFP2-WPRE3-BGHpADirect-expressing SYFP2 AAV virus
223945HCT55_rAAV-eHGT453m_eHGT_1137m-minBGprom-SYFP2-WPRE3-bGHpADirect-expressing SYFP2 AAV virus
233558HCT159_pAAV-eHGT_3Xcore_1137m-minBGprom-iCre297T-WPRE3-bGHpADirect-expressing iCre297T AAV virus
233559HCT160_pAAV-3X-eHGT_1139m-minBGprom-iCre297T-WPRE3-bGHpADirect-expressing iCre297T AAV virus
233562HCT163_pAAV-eHGT_3Xcore_1137m-minBGprom-ChR2(H134R)-EYFP-WPRE3-bGHpADirect-expressing ChR2(H134R)-EYFP AAV virus
233563HCT164_pAAV-3X-eHGT_1139m-minBGprom-ChR2(H134R)-EYFP-WPRE3-bGHpADirect-expressing ChR2(H134R)-EYFP AAV virus
233564HCT47_pAAV-eHGT_3Xcore_1137m-minBGprom-iCre297T-WPRE3-bGHpADirect-expressing SYFP2 AAV virus
234712AiP14358 - pAAV-CAG-SYFP2-WPRE-SV40pA (Alias: CN4358)Direct-expressing SYFP2 AAV virus

Antibodies from Article