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An adaptive peptide-binding site in ubiquitin receptor hRpn13 revealed by structural studies.

Hassan B, Chandravanshi M, Ng MY, Negi H, Wilson BAP, Walters KJ
Nat Commun. 2025 Jul 1;16(1):5669. doi: 10.1038/s41467-025-60843-w. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
225429ADRM1_MTT_Del_pGEX-4T-1Expresses a truncated construct of hRpn13 Pru having deletion at the N-terminus
237412pET_3a_Ub_ENTExpresses Ubiquitin with a disordered tail from the extreme N terminus of Rpn13
237413pET_3a_Ub_EDGEGEEExpresses Ubiquitin with a disordered tail with an acidic sequence
237414ADRM1_MTT_Del_pGEX-4T-1 with Stop CodonExpresses hRpn13 without the first three residues (MTT) of the native sequence

Antibodies from Article