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Engineered interleukin-6-derived cytokines recruit artificial receptor complexes and disclose CNTF signaling via the OSMR.

Rafii P, Cruz PR, Ettich J, Seibel C, Padrini G, Wittich C, Lang A, Petzsch P, Kohrer K, Moll JM, Floss DM, Scheller J
J Biol Chem. 2024 May;300(5):107251. doi: 10.1016/j.jbc.2024.107251. Epub 2024 Apr 1. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
213389GIL-6Expresses a chimeric cytokine between IL-6 and LIF
213390GIO-6Expresses a chimeric cytokine between IL-6 and OSM

Antibodies from Article