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Synthetic serum markers enable noninvasive monitoring of gene expression in primate brains.

Lee S, Romac MD, Watanabe S, Chernov M, Li H, Raisley E, Rothenhoefer KM, Dahlquist Z, Szablowski JO, Costa VD
Neuron. 2026 Feb 27:S0896-6273(26)00003-6. doi: 10.1016/j.neuron.2026.01.003. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
227886pAAV-hSyn-Gluc-NHP.RMA-IRES-EGFPExpresses Gluc-NHP.RMA and EGFP under the hSyn promoter. Gluc-NHP.RMA for monitoring neuronal transduction.
227887pAAV-hSyn-DIO-Gluc-NHP.RMA-IRES-EGFPExpresses Gluc-NHP.RMA and EGFP in the presence of Cre recombinase. Double-floxed Gluc-NHP.RMA and EGFP for monitoring Cre-expressing neuronal populations.
227888pAAV-hSyn-Cluc-NHP.RMAExpresses Cluc-NHP.RMA under the hSyn promoter. Cluc-NHP.RMA for monitoring neuronal transduction.

Antibodies from Article