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Rational Design of Enhanced Nme2Cas9 and Nme2(Smu)Cas9 Nucleases and Base Editors.

Bamidele N, Ansodaria A, Chen Z, Cheng H, Panwala R, Jazbec E, Sontheimer EJ
bioRxiv [Preprint]. 2024 Nov 7:2024.10.30.620986. doi: 10.1101/2024.10.30.620986. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
228717pEJS2696-CMV-Nme2SmuCas9-D56RExpresses Nme2Smu Cas9 nuclease with D56R mutation in mammalian cells
228718pEJS2697-CMV-Nme2SmuCas9-E932RExpresses Nme2Smu Cas9 nuclease with E932R mutation in mammalian cells
228719pEJS2698-CMV-Nme2Cas9-D56RExpresses Nme2 Cas9 nuclease with D56R mutation in mammalian cells
228720pEJS2699-CMV-Nme2Cas9-E932RExpresses Nme2 Cas9 nuclease with E932R mutation in mammalian cells
228721pEJS2700-CMV-Nme2-ABE8e-nt-E932RExpresses N-terminal ABE8e-Nme2 nCas9 (D16A) base editor with E932R mutation in mammalian cells
228722pEJS2701-CMV-Nme2Smu-ABE8e-nt-E932RExpresses N-terminal ABE8e-Nme2Smu nCas9 (D16A) base editor with E932R mutation in mammalian cells
228723pEJS2702-CMV-iNme2-ABE8e-ntExpresses N-terminal ABE8e-iNme2 nCas9 (D16A) base editor in mammalian cells
228724pEJS2703-CMV-iNme2Smu-ABE8e-ntExpresses N-terminal ABE8e-iNme2Smu nCas9 (D16A) base editor in mammalian cells
228725pEJS2704-CMV-Nme2Smu-ABE8e-i8-L10-E932RExpresses domain inlaid Nme2Smu nCas9 (D16A)-i8-ABE8e base editor with linker-10 and E932R mutation in mammalian cells
228726pEJS2705-CMV-Nme2Smu-ABE8e-i8-L10-D56RExpresses domain inlaid Nme2Smu nCas9 (D16A)-i8-ABE8e base editor with linker-10 and D56R mutation in mammalian cells
228727pEJS2706-CMV-Nme2-ABE8e-i8-L10-E932RExpresses domain inlaid Nme2 nCas9 (D16A)-i8-ABE8e base editor with linker-10 and E932R mutation in mammalian cells
228728pEJS2707-CMV-Nme2-ABE8e-i8-L10-D56RExpresses domain inlaid Nme2 nCas9 (D16A)-i8-ABE8e base editor with linker-10 and D56R mutation in mammalian cells
228729pEJS2708-CMV-Nme2Smu-ABE8e-i1-L10-E932RExpresses domain inlaid Nme2Smu nCas9 (D16A)-i1-ABE8e base editor with linker-10 and E932R mutation in mammalian cells
228730pEJS2709-CMV-Nme2Smu-ABE8e-i1-L10-D56RExpresses domain inlaid Nme2Smu nCas9 (D16A)-i1-ABE8e base editor with linker-10 and D56R mutation in mammalian cells
228731pEJS2710-CMV-Nme2-ABE8e-i1-L10-E932RExpresses domain inlaid Nme2 nCas9 (D16A)-i1-ABE8e base editor with linker-10 and E932R mutation in mammalian cells
228732pEJS2711-CMV-Nme2-ABE8e-i1-L10-D56RExpresses domain inlaid Nme2 nCas9 (D16A)-i1-ABE8e base editor with linker-10 and D56R mutation in mammalian cells
228733pEJS2712-CMV-eNme2-C-ABE8e-i1-L10Expresses domain inlaid eNme2-C nCas9 (D16A)-i1-ABE8e base editor with linker-10 in mammalian cells
228734pEJS2713-CMV-iNme2-ABE8e-i1-L10Expresses domain inlaid iNme2 nCas9 (D16A)-i1-ABE8e base editor with linker-10 in mammalian cells
228735pEJS2714-CMV-iNme2Smu-ABE8e-i1-L10Expresses domain inlaid iNme2Smu nCas9 (D16A)-i1-ABE8e base editor with linker-10 in mammalian cells

Antibodies from Article