A STING-CASM-GABARAP pathway activates LRRK2 at lysosomes.
Bentley-DeSousa A, Roczniak-Ferguson A, Ferguson SM
J Cell Biol. 2025 Feb 3;224(2):e202310150. doi: 10.1083/jcb.202310150. Epub 2025 Jan 15.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 229738 | pPB-EF1A-HALO-hLRRK2 | Expresses Halo tagged human LRRK2 in mammalian cells. Stable expression with piggybac transposase. |
| 229739 | pPB-EF1A-mSTING | Expresses mouse STING in mammalian cells. Stable expression with piggybac transposase. |
| 229740 | pPB-EF1A-mSTING (1-339) | Expresses mouse STING amino acids 1-339 in mammalian cells. Stable expression with piggybac transposase. |
| 229741 | pPB-HA-hGABARAP | Expresses HA-tagged human GABARAP in mammalian cells. Stable expression with piggybac transposase. |
| 229742 | pPB-EF1A-HALO-hLRRK2 (LIR1 mutant WEVL -> AEVA) | Expresses Halo tagged human LRRK2 with LIR1 point mutations in mammalian cells. Stable expression with piggybac transposase. |
| 229743 | pPB-EF1A-HALO-hLRRK2 (LIR2 mutant WTFI -> ATFA) | Expresses Halo tagged human LRRK2 with LIR2 point mutations in mammalian cells. Stable expression with piggybac transposase. |
| 229744 | pPB-EF1A-HALO-hLRRK2 (LIR1+2 mutant WEVL -> AEVA / WTFI -> ATFA) | Expresses Halo tagged human LRRK2 with LIR1 and LIR2 point mutations in mammalian cells. Stable expression with piggybac transposase. |
| 229745 | pPB-mCherry-SopF | Expresses mCherry-tagged SopF in mammalian cells. Stable expression with piggybac transposase. |