Customizable virus-like particles deliver CRISPR-Cas9 ribonucleoprotein for effective ocular neovascular and Huntington's disease gene therapy.
Ling S, Zhang X, Dai Y, Jiang Z, Zhou X, Lu S, Qian X, Liu J, Selfjord N, Satir TM, Lundin A, Touza JL, Firth M, Van Zuydam N, Bilican B, Akcakaya P, Hong J, Cai Y
Nat Nanotechnol. 2025 Apr;20(4):543-553. doi: 10.1038/s41565-024-01851-7. Epub 2025 Feb 10.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 229772 | pU6-Osp.gRNA-MS2in | Contains the U6 promoter and an optimized gRNA backbone inserted with two copies of the MS2 stem loop. |
| 229773 | pCMV-2NLS-Cas9 | Expresses Cas9 driven by a CMV promoter |