De novo design of peptide binders to conformationally diverse targets with contrastive language modeling.
Bhat S, Palepu K, Hong L, Mao J, Ye T, Iyer R, Zhao L, Chen T, Vincoff S, Watson R, Wang T, Srijay D, Kavirayuni VS, Kholina K, Goel S, Vure P, Desphande AJ, Soderling SH, DeLisa MP, Chatterjee P
Sci Adv. 2025 Jan 24;11(4):eadr8638. doi: 10.1126/sciadv.adr8638. Epub 2025 Jan 22.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 232088 | PC1575 | Mammalian expression plasmid for ubiquibody (uAb) cloning backbone. Includes an Esp3I restriction site directly upstream of GSGSG linker and CHIPΔTPR CDS and a C-terminal IRES-mCherry cassette. |