Structural insight into the cGAS active site explains differences between therapeutically relevant species.
Skeldon AM, Wang L, Sgarioto N, Beveridge RE, Chan S, Dorich S, Dumais V, Fradet N, Gaudreault S, LeGros P, McKay D, Seliniotakis R, Sietsema DV, Zhang L, Boily MO, Burch JD, Caron A, Fader LD, Lama L, Xie W, Patel DJ, Tuschl T, Crackower MA, Pike KA
Commun Chem. 2025 Mar 22;8(1):88. doi: 10.1038/s42004-025-01481-7.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 232294 | pRSFDuet-SUMO-h-cGAS(T321I) | Expression of mutant human cGAS protein (T321I) |
| 232295 | pRSFDuet-SUMO-m-cGAS(I309T) | Expression of mutant mouse cGAS protein (I309T) |