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YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies.

Chen Z, Zeng C, Yang L, Che Y, Chen M, Sau L, Wang B, Zhou K, Chen Y, Qing Y, Shen C, Zhang T, Wunderlich M, Wu D, Li W, Wang K, Leung K, Sun M, Tang T, He X, Zhang L, Swaminathan S, Mulloy JC, Muschen M, Huang H, Weng H, Xiao G, Deng X, Chen J
Cell. 2024 Dec 12:S0092-8674(24)01324-2. doi: 10.1016/j.cell.2024.11.007. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
232944pCDH-3_Flag-PABPC1Expresses PABPC1 protein
232945pCDH-3_Flag-YTHDF2 (nonsense mutation of sgYTHDF2-1)Expresses YTHDF2 with synonymous mutations rendering it resistant to sgYTHDF2-1-mediated knockdown
232946pCDH-3_Flag-YTHDF2-m(6)A-MUT (nonsense mutation of sgYTHDF2-1)Expresses the m6A-binding-deficient mutant of YTHDF2 with synonymous mutations for resistance against sgYTHDF2-1-mediated knockdown
232947pCDH-3_Flag-YTHDF2-D-MUT (nonsense mutation of sgYTHDF2-1)Expresses the domain-mutant YTHDF2 with synonymous mutations for resistance against sgYTHDF2-1-mediated knockdown
232948pCDH-3_Flag-YTHDF2-RNA-MUT (nonsense mutation of sgYTHDF2-1)Expresses the RNA-binding-deficient mutant of YTHDF2 with synonymous mutations for resistance against sgYTHDF2-1-mediated knockdown
232949pCDH-3_Flag-ATP5PBExpresses ATP5PB
232950pCDH-3_Flag-ATP5MFExpresses ATP5MF
232951PSIN4-3_Flag-ATP5MGExpresses ATP5MG
232952MSCV-BCR-ABL1Expresses BCR-ABL1 fusion protein
232953MSCV-NRAS(G12D)-NeoExpresses mutant form of NRAS

Antibodies from Article