A stress-dependent TDP-43 SUMOylation program preserves neuronal function.
Suk TR, Part CE, Zhang JL, Nguyen TT, Heer MM, Caballero-Gomez A, Grybas VS, McKeever PM, Nguyen B, Ali T, Callaghan SM, Woulfe JM, Robertson J, Rousseaux MWC
Mol Neurodegener. 2025 Mar 28;20(1):38. doi: 10.1186/s13024-025-00826-z.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 235487 | pEGFP-TDP-43 | Expression of human TDP-43-EGFP |
| 235488 | pEGFP-TDP-43 (Q331K) | Expression of human TDP-43-EGFP with human ALS-causing Q331K mutation |
| 235491 | pEGFP-TDP-43 (5FL) | Expression of human RNA-binding deficient TDP-43-EGFP |
| 235492 | pEGFP-TDP-43 (K136R) | Expression of human TDP-43-EGFP with K136R mutation |
| 235493 | pEGFP-TDP-43 (K408R) | Expression of human TDP-43-EGFP with K408R mutation to block SUMOylation |
| 235494 | pEGFP-TDP-43 (2KR) | Expression of human TDP-43-EGFP with K136R and K408R mutations |
| 235495 | pDEST-TDP-43-SUMO2-HA | Expression of human TDP-43-SUMO2-HA fusion protein |
| 235496 | pDEST-TDP-43-HA | Expression of human TDP-43-HA fusion protein |
| 235497 | pL302-HA-SUMO2 | Expression of HA-SUMO2 |
| 235498 | pLV-Hspa1l-mRuby2 | Lentiviral expression of Hspa1l-mRuby2 |
| 235499 | pEGFP-TDP-43 (4SA) | Expression of human TDP-43-EGFP with phospho-dead mutations in the C-terminus |
| 235500 | pENTR-TDP-43-SUMO2-HA | Entry clone with TDP-43-SUMO2-HA insert |
| 235501 | pENTR-TDP-43-HA | Entry clone with TDP-43-HA insert |